Yamanaka factors reset a cell to a stem‑like state
OSKM · Altos Labs
STATE
Differentiated cell — aged
EPIGENETIC AGE
OLDYOUNG
Oct4
Sox2
Klf4
c‑Myc
Oct4 · Sox2 · Klf4 · c‑Myc are transcription‑factor proteins. They enter an aged cell, dock onto DNA in the nucleus, and rewind its epigenetic age toward an induced pluripotent stem cell. Auto‑orbit; click the scene to play / pause.